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College of Nursing & Health Sciences, Flinders Uni

Digital Health Research Methods

Agile research methods in Digital Health

In order to accommodate innovation and the various issues that need to be evaluated in a Digital Health intervention, such as safety, feasibility and effectiveness, agile research methods that are not commonly used in Health should be considered. In this section, you will be able to find references to innovative methods that are useful to research in Digital Health.

Multiphase Optimization STrategy (MOST) research framework

  • Home Visit Applied Research Collaborative (HARC) [website] - presents an overview of the Multiphase Optimization Strategy (MOST) research framework
  • Penn State College of Health and Human Development: The Methodology Center [website] - provides a comprehensive summary of the MOST framework including terminology and descriptions of the different phases of research
  • Kate Guastaferro (2018) from the HARC organisation presenting at the HARC 2018 Methods Meeting in Chicago (US) explaining how to apply the Multiphase Optimization Strategy (MOST) framework [YouTube clip 15:40mins]
  • Introduction to Multiphase optimization strategy (MOST) 
    (638kb PDF) PowerPoint presentation from the 2017 'New Experimental Approaches to Designing Effective Multi-Component Interventions' workshop given by Dr Linda Collins. This presentation introduces the MOST framework and provides an example of how this is applied within a research project


Just-In-Time Adaptative Interventions (JITAIs)


Sequential, Multiple Assignment, Randomized Trials (SMARTs)

  • The Methodology Center [Blogsite] Building Better Adaptive Interventions by Expanding SMART by Dr John Dziak (published online June 27 2019) describes how SMART experimental designs can build adaptive interventions to address many health and behavioural challenges including examples of pilot programs using SMARTs and JITAIs
  • 2013 Lecture resource from Michael Kosorok (University of North Carolina Shep's Centre for Health Services Research) on 
    Introduction to Design and Analysis of SMARTs (520kb PDF) including descriptions of statistical analyses of results from SMART research trials
  • Introduction to Adaptive Interventions and SMART Study Design Principles (1.6Mb PDF ) PowerPoint presentation from the 2011 'Introduction to Adapt COPTR Workshop on Adaptive Interventions' workshop given by Dr Daniel Almirall. This presentation introduces SMART research design and discusses the differences between adaptive designs and interventions




 Page updated 23 December 2019